EVALUATION OF THE POTENTIAL HERB-DRUG INTERACTION BETWEEN BOJUNGIKKI-TANG AND PD-L1 IMMUNOTHERAPY IN A SYNGENEIC MOUSE MODEL

Evaluation of the potential herb-drug interaction between Bojungikki-tang and PD-L1 immunotherapy in a syngeneic mouse model

Atezolizumab (a PD-L1 inhibitor) has shown remarkable efficacy and tolerability in various cancer types.Despite its efficacy and safety, atezolizumab monotherapy has limitations, such as acquired resistance and adverse events.Bojungikki-tang (BJIKT) is an herbal decoction widely prescribed in Asian countries and used to treat cancer-related symptom

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The suspended sentence in German criminal law

From the ancient times until today, criminal law in all countries has provided different criminal sanctions as social control measures.These are court-imposed coercive measures that take away or limit certain rights and freedoms of criminal offenders.Sanctions are applied to natural or legal Neff N90 C18FT56N1B Steam Oven persons who violate the no

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Optimization for Risk Decision-Making Through Simulated Annealing

In this paper, a computational methodology combining the simulated Hair Removal Creams annealing algorithm with two machine learning techniques to select a near-optimal safeguard set for business risk response is presented.First, a mathematical model with four types of risk factor responses (avoid, mitigate, transfer, and accept) is constructed.The

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Inelastic Dirac dark matter

Abstract Feebly interacting thermal relics are promising dark matter candidates.Among them, scenarios of inelastic Dark Matter evade direct detection by suppressed elastic scattering off atomic nuclei.We introduce inelastic Dirac Dark Matter, a new model with two Dirac fermions in the MeV-GeV mass range.At feeble couplings, dark Ginger matter can d

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